Finding new ways to help repair nerve damage in Multiple Sclerosis
Accelerating remyelination using lanthionine ketimine derivatives
This study is looking for new ways to help people with Multiple Sclerosis by testing a special compound that might speed up the healing of nerve coverings, which could improve how their nerves work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jesse Brown VA Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10910001 on NIH RePORTER |
What this research studies
This research focuses on discovering new compounds that can speed up the repair of myelin, the protective covering of nerves, in patients with Multiple Sclerosis (MS). Unlike most treatments that aim to reduce immune system damage, this project seeks to enhance the body's ability to regenerate myelin through the use of a semi-synthetic amino acid derivative called Lanthionine Ketimine Ester (LKE). The research involves testing various LKE derivatives in laboratory models to determine their effectiveness in promoting remyelination and improving nerve function. By optimizing dosages and treatment durations, the study aims to provide insights into how these compounds can restore nerve function in MS patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have been diagnosed with Multiple Sclerosis.
Not a fit: Patients with other neurological disorders that do not involve demyelination may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery and quality of life for patients with Multiple Sclerosis.
How similar studies have performed: Previous research has shown promise in using similar approaches to enhance remyelination, but this specific method is relatively novel.
Where this research is happening
Chicago, United States
- Jesse Brown VA Medical Center — Chicago, United States (Active)
Researchers
- Principal investigator: Feinstein, Douglas L. — Jesse Brown VA Medical Center
- Study coordinator: Feinstein, Douglas L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.