Finding new ways to help repair nerve damage in Multiple Sclerosis
Official title: Accelerating remyelination using lanthionine ketimine derivatives
Funded at Jesse Brown VA Medical Center · NIH-10910001 · Data updated 2026-11-12
This study is looking for new ways to help people with Multiple Sclerosis by testing a special compound that might speed up the healing of nerve coverings, which could improve how their nerves work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jesse Brown VA Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | October 1, 2022 |
| Project end | September 30, 2027 |
| Funding year | 2024 |
| NIH project number | 5I01RX003955-03 |
| Project ID | NIH-10910001 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have been diagnosed with Multiple Sclerosis.
✕Less likely to help
Patients with other neurological disorders that do not involve demyelination may not benefit from this research.
What this research studies
This research focuses on discovering new compounds that can speed up the repair of myelin, the protective covering of nerves, in patients with Multiple Sclerosis (MS). Unlike most treatments that aim to reduce immune system damage, this project seeks to enhance the body's ability to regenerate myelin through the use of a semi-synthetic amino acid derivative called Lanthionine Ketimine Ester (LKE). The research involves testing various LKE derivatives in laboratory models to determine their effectiveness in promoting remyelination and improving nerve function. By optimizing dosages and treatment durations, the study aims to provide insights into how these compounds can restore nerve function in MS patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve recovery and quality of life for patients with Multiple Sclerosis.
How similar studies have gone: Previous research has shown promise in using similar approaches to enhance remyelination, but this specific method is relatively novel.
Where this research is happening
-
Jesse Brown VA Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Feinstein, Douglas L. — Jesse Brown VA Medical Center
- Study coordinator: Feinstein, Douglas L.
Related research
Other NIH-funded projects on the same topics.
-
New ways to stop rheumatoid arthritis damage and relieve pain
Researchers are testing novel targets to prevent the problematic tissue growth in rheumatoid arthritis so people, including veterans, can move more freely and feel better.
-
SHAPE: a wearable shoulder-and-hand device to help after stroke
This project will build and try a wearable device that supports the shoulder and helps move the hand for people with long-standing arm problems after a stroke.
-
SHAPE: a shoulder-and-hand wearable to help people with long-term arm weakness after stroke
This project is building and trying out a wearable device that supports the shoulder and powers the hand to help people with chronic arm weakness after stroke.
-
Prosthetic foot and ankle stiffness for above-knee amputees' walking and standing
This project changes stiffness in prosthetic feet and ankles to find settings that help people with above-knee amputations walk and stand better without making their prosthetic knee unstable.
-
Helping Veterans speak up and make shared decisions about their diabetes care
This project offers a brief video-based program to help Veterans with type 2 diabetes communicate better with their doctors and stick to treatment plans.
-
Do Powered Knee Prostheses Improve Mobility for Transfemoral Amputees
A new powered knee prosthesis with motor-assisted bending and straightening is being tested to see if it improves walking for people who have lost a leg above the knee.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.