Finding new ways to enhance health in older adults
Improving healthspan through discovery of potent NAMPT activators from a DNA-encoded library
This study is looking for new ways to boost a helpful enzyme called NAMPT, which can improve health as we age, especially for older adults dealing with heart and metabolic issues.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-10697352 on NIH RePORTER |
What this research studies
This research aims to discover new activators of an enzyme called NAMPT, which plays a crucial role in producing NAD+, a molecule important for cellular health. By developing and testing these activators in preclinical models, the research seeks to understand how they can help reverse age-related health issues, particularly those related to cardiovascular and metabolic diseases. The approach involves screening a library of compounds to identify those that effectively boost NAMPT activity and improve healthspan in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related health issues, particularly those related to cardiovascular and metabolic conditions.
Not a fit: Patients who are younger and do not have age-related health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance health and longevity in older adults.
How similar studies have performed: Previous research has shown promising results with similar approaches targeting NAD+ metabolism, but this specific focus on NAMPT activators is relatively novel.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Donato, Anthony John — University of Utah
- Study coordinator: Donato, Anthony John
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.