Finding new ways to block HIV
Identification of HIV Rev-Rev interaction inhibitors by a high throughput, small molecule, cell-free screen
This project aims to discover new medications that stop the HIV virus from multiplying by targeting a key viral protein.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11163476 on NIH RePORTER |
What this research studies
Even with current treatments, many people living with HIV still need new options due to side effects, drug interactions, or resistance. This project focuses on a vital HIV protein called Rev, which the virus needs to make more copies of itself. Researchers are developing a special laboratory test to quickly find small molecules that can block the Rev protein from working. The hope is that these new molecules could lead to a completely new type of HIV medication.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but aims to benefit individuals living with HIV who may need new treatment options in the future.
Not a fit: Patients currently stable on existing HIV therapies may not see immediate direct benefit from this early-stage drug discovery work.
Why it matters
Potential benefit: If successful, this work could lead to the development of a new class of anti-HIV drugs that target a previously unaddressed viral mechanism, potentially offering new treatment options for patients.
How similar studies have performed: While some compounds in clinical trials aim to interfere with Rev function, there are currently no FDA-approved drugs that specifically target Rev's known mechanism of action, making this a novel approach.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Sutton, Richard — Yale University
- Study coordinator: Sutton, Richard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.