Finding new vaccine helpers to boost immunity against certain infections
Official title: Identification of Novel Syk/Raf-1 Mediated CLR Ligands as Vaccine Adjuvants
Funded at University of Montana · NIH-11203002 · Data updated 2026-11-12
This study is looking for new substances that can boost the immune system's ability to fight off bacterial and fungal infections, like tuberculosis and coccidioidomycosis, and it aims to see how these substances work in people of different ages.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Montana NIH-funded |
| Lab location | 1 site (Missoula, United States) |
| Project start | September 30, 2024 |
| Project end | September 29, 2029 |
| Funding year | 2024 |
| Award (this year) | $1,637,656 |
| NIH project number | 75N93024C00024-0-9999-1 |
| Project ID | NIH-11203002 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would be individuals at risk for infections caused by Mycobacterium tuberculosis or coccidioidomycosis, particularly those with age-related immune challenges.
✕Less likely to help
Patients who are not at risk for these specific infections or who have already been vaccinated may not benefit from this research.
What this research studies
This research focuses on identifying new compounds that can enhance the immune response to bacterial and fungal infections, specifically targeting Mycobacterium tuberculosis and coccidioidomycosis. The approach involves screening synthetic compounds to find those that stimulate specific immune responses, particularly in different age groups. The research will utilize both mouse models and human cell studies to evaluate the effectiveness of these compounds as vaccine adjuvants, which are substances that improve the body's immune response to vaccines.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines that provide better protection against serious infections.
How similar studies have gone: Other research has shown promise in using similar approaches to enhance vaccine efficacy, indicating potential for success in this area.
Where this research is happening
-
University of Montana
Missoula, United States Active
Researchers
- Principal investigator: Evans, Jay — University of Montana
- Study coordinator: Evans, Jay
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.