Finding new uses for existing drugs to treat Alzheimer's disease
Drug repositioning for Alzheimer's disease via genetics, electronic health records, and human iPSC models
This study is looking at how some already-approved medications might be used to help treat Alzheimer's disease by using genetic information and health records, with the goal of finding new ways to speed up effective treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-10994622 on NIH RePORTER |
What this research studies
This research investigates how existing FDA-approved drugs can be repurposed to treat Alzheimer's disease (AD) by utilizing genetic data, electronic health records, and human-induced pluripotent stem cell (iPSC) models. The team will analyze genetic factors associated with AD to identify potential drug candidates that could be effective in treating the disease. By combining insights from genetics and health records, the research aims to enhance the understanding of AD pathology and improve drug discovery efforts. Patients may benefit from this innovative approach that seeks to expedite the availability of effective treatments for Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those at high risk due to genetic factors.
Not a fit: Patients with non-Alzheimer's forms of dementia or those without genetic risk factors for Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for Alzheimer's disease, potentially improving the quality of life for patients.
How similar studies have performed: Previous research has shown promise in drug repurposing for other conditions, suggesting that this approach could be effective for Alzheimer's as well.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Li, Bingshan — Vanderbilt University
- Study coordinator: Li, Bingshan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.