Finding new uses for existing drugs to fight fungal infections
Screening a Target-Based Repurposing Library for Activity against Fungal Pathogens and Subsequent Preclinical Development of Leading Candidates
This study is looking at how we can use some already-approved medications to find better and safer treatments for fungal infections that can be really dangerous for people with weakened immune systems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas San Antonio NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10544529 on NIH RePORTER |
What this research studies
This research investigates the potential of repurposing existing drugs to combat fungal infections that pose significant risks to patients with weakened immune systems. By screening a library of compounds, the team aims to identify effective treatments against common fungal pathogens like Candida, Aspergillus, and Cryptococcus. The approach focuses on discovering new antifungal agents that can overcome the limitations of current treatments, which often have high toxicity and resistance issues. Patients may benefit from improved therapeutic options that are safer and more effective.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with compromised immune systems, such as those undergoing chemotherapy, organ transplant recipients, or patients with HIV/AIDS.
Not a fit: Patients with fungal infections that are not caused by the targeted pathogens or those who are not immunocompromised may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antifungal treatments that significantly reduce morbidity and mortality associated with fungal infections.
How similar studies have performed: Previous research has shown promise in repurposing existing drugs for various conditions, indicating potential success for this novel approach in antifungal treatment.
Where this research is happening
San Antonio, United States
- University of Texas San Antonio — San Antonio, United States (Active)
Researchers
- Principal investigator: Lopez-Ribot, Jose L. — University of Texas San Antonio
- Study coordinator: Lopez-Ribot, Jose L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.