Finding new treatments for parasitic worm infections
Identification of novel anthelmintics through a target-based screen of a parasite ion channel
This study is looking for new medicines to help treat infections from parasitic worms, like schistosomiasis, by finding better ways to target a specific part of the parasite that current treatments rely on, which could lead to more effective options for everyone affected.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-10774246 on NIH RePORTER |
What this research studies
This research focuses on developing new medications to treat infections caused by parasitic worms, particularly schistosomiasis, which affects millions worldwide. The team has identified a specific ion channel in the parasite that is crucial for the action of the current treatment, praziquantel. By screening for new compounds that can target this ion channel, the researchers aim to discover more effective anthelmintics that can overcome the limitations of existing therapies. This approach could lead to treatments that are effective against all stages of the parasite's life cycle.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals infected with schistosomiasis or other parasitic worm infections, particularly those who have not responded well to current treatments.
Not a fit: Patients who are not infected with parasitic worms or those who have already been effectively treated with existing medications may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide more effective treatments for parasitic worm infections, improving health outcomes for millions of affected individuals.
How similar studies have performed: Previous research has successfully identified targets for existing anthelmintics, suggesting that this approach has the potential for meaningful advancements in treatment.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Marchant, Jonathan S — Medical College of Wisconsin
- Study coordinator: Marchant, Jonathan S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.