Finding new treatments for neurodevelopmental disorders using AI and gene data
Official title: Identifying potential therapeutics for neurodevelopmental disorders using artificial intelligence and transcriptional data
Funded at Baylor College of Medicine · NIH-11067425 · Data updated 2026-11-12
This study is using smart computer technology to find new treatments for neurodevelopmental disorders by looking at how certain drugs can help fix problems with genes, especially focusing on a gene called MeCP2, so that we can better address the root causes of these conditions instead of just treating the symptoms.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | December 1, 2024 |
| Project end | May 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $49,362 |
| NIH project number | 1F30HD117505-01 |
| Project ID | NIH-11067425 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with neurodevelopmental disorders, particularly those linked to gene imbalances.
✕Less likely to help
Patients with neurodevelopmental disorders that do not involve gene expression imbalances may not benefit from this research.
What this research studies
This research aims to identify potential therapeutics for neurodevelopmental disorders (NDDs) by utilizing artificial intelligence (AI) to analyze extensive gene expression data. The project will leverage publicly available RNA-sequencing studies to understand how specific drugs can modulate gene products that are either deficient or excessive in these disorders. By creating an automated prediction pipeline, the research will prioritize the most promising treatments for further testing, focusing on the gene methyl-CpG-binding protein 2 (MeCP2). This innovative approach seeks to move beyond symptomatic treatment and target the underlying genetic causes of NDDs.
Why it matters
Potential benefit: If successful, this research could lead to new, targeted therapies that address the root causes of neurodevelopmental disorders rather than just alleviating symptoms.
How similar studies have gone: Previous research has shown promise in using AI and gene expression data to identify potential therapeutics, indicating that this approach could be effective.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Deisseroth, Cole — Baylor College of Medicine
- Study coordinator: Deisseroth, Cole
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.