Finding new treatments for kidney transplant rejection
Computational Drug Repositioning for Antibody Mediated Renal Allograft Rejection
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11126715
This study is looking for better ways to treat kidney transplant patients who are experiencing antibody-mediated rejection by finding new uses for existing medications based on their unique gene profiles.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11126715 on ClinicalTrials.gov |
What this research studies
This research focuses on improving treatments for antibody-mediated rejection (ABMR) in kidney transplant patients. By analyzing gene expression profiles from kidney biopsies, the team aims to identify existing drugs that could be repurposed to treat this condition. The approach involves using advanced computational methods to match drug candidates with the specific molecular characteristics of ABMR. Patients may benefit from more effective therapies tailored to their unique rejection profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research are kidney transplant recipients experiencing antibody-mediated rejection.
Not a fit: Patients who have not undergone kidney transplantation or those without antibody-mediated rejection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for kidney transplant rejection, improving graft survival rates.
How similar studies have performed: Previous research has shown promise in using computational methods for drug repurposing, indicating potential success for this approach.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SARWAL, MINNIE M — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: SARWAL, MINNIE M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.