Finding new treatments for high-risk medulloblastoma in children
Identifying Novel Therapeutics for High Risk Medulloblastoma Patients
This study is looking for better ways to treat children with high-risk medulloblastoma, a type of brain tumor, by exploring new treatments that focus on specific changes in the tumor's genes, especially when there's a mutation in the P53 gene, to help improve their chances of recovery and reduce the chance of the tumor coming back.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-11017037 on NIH RePORTER |
What this research studies
This research focuses on improving outcomes for children diagnosed with high-risk medulloblastoma, a common pediatric brain tumor. It aims to identify novel therapeutic approaches by targeting specific molecular pathways associated with tumor growth, particularly in cases where the tumor has mutations in the P53 gene. By utilizing advanced genomic techniques, the research seeks to better understand the tumor's biology and develop targeted treatments that could reduce the risk of relapse and improve survival rates. The study involves analyzing tumor samples and signaling networks to find effective treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who have been diagnosed with high-risk medulloblastoma, particularly those with P53 mutations.
Not a fit: Patients with low-risk medulloblastoma or those who do not have P53 mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for high-risk medulloblastoma, potentially improving survival rates and reducing long-term side effects for affected children.
How similar studies have performed: Previous research has shown promise in targeting specific molecular pathways in cancer treatment, indicating that this approach could be effective for medulloblastoma as well.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Rodriguez-Blanco, Jezabel — Medical University of South Carolina
- Study coordinator: Rodriguez-Blanco, Jezabel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.