Finding New Treatments for High-Risk Cancers in Children and Young Adults
Official title: A Testing Program to Identify Novel Agents for Treatment of Pediatric and AYA High-Risk Sarcoma, Kidney and Liver Cancer
Funded at University of Texas Hlth Science Center · NIH-11142597 · Data updated 2026-11-12
This research looks for new medicines and combinations to treat aggressive sarcomas, kidney, and liver cancers in children and young adults.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | September 1, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $593,085 |
| NIH project number | 5U01CA263981-05 |
| Project ID | NIH-11142597 on NIH RePORTER |
Who could benefit from this research
✓Could help
This preclinical research is focused on finding treatments for children and young adults (up to 21 years old) diagnosed with high-risk sarcoma, kidney cancer, or liver cancer.
✕Less likely to help
Patients with other types of cancer or those outside the pediatric and young adult age range may not directly benefit from the specific findings of this research.
What this research studies
We are working to discover new and better treatments for rare, high-risk cancers that affect children and young adults. Our team uses special models, called patient-derived xenografts (PDX), which are developed from actual patient tumors, to test many different potential drugs and combinations. This helps us understand which treatments might work best against these specific cancers before they are tested in people. Our goal is to find effective new therapies that can improve outcomes for young patients who have limited treatment options.
Why it matters
Potential benefit: If successful, this work could lead to the discovery of new and more effective drug treatments for pediatric and young adult high-risk sarcomas, kidney, and liver cancers.
How similar studies have gone: Our group has previously contributed to preclinical studies that have successfully led to new clinical trials through the Children's Oncology Group (COG).
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Kurmasheva, Raushan — University of Texas Hlth Science Center
- Study coordinator: Kurmasheva, Raushan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.