Finding new treatments for glioblastoma using DNA aptamers
In vivo SELEX strategies to identify potent aptamer-drug conjugates for glioblastoma
This study is exploring new ways to treat glioblastoma, a tough type of brain cancer, by using special DNA pieces that can help deliver medicine directly to the tumor, making treatments more effective.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10910176 on NIH RePORTER |
What this research studies
This research focuses on developing innovative therapies for glioblastoma, a challenging brain cancer. The approach involves using DNA aptamers, which are small pieces of DNA that can bind to specific targets in the tumor, to create drug conjugates that can effectively cross the blood-brain barrier. By employing advanced techniques like SELEX, researchers aim to identify aptamers that can deliver drugs directly to the tumor cells, potentially improving treatment outcomes. This study seeks to address the limitations of current therapies by enhancing drug delivery to the brain.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have been diagnosed with glioblastoma.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma, improving survival rates and quality of life for patients.
How similar studies have performed: Previous research has shown promise in using aptamers for targeted drug delivery, indicating that this approach could be a significant advancement in glioblastoma treatment.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Sarkaria, Jann N. — Mayo Clinic Rochester
- Study coordinator: Sarkaria, Jann N.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.