Finding New Treatments for Endometriosis Pain
Leveraging Omics-Based Computational Approaches to Identify and Validate Novel Therapeutic Candidates for Endometriosis
['FUNDING_P01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11158753
This project looks for new and better drug treatments for endometriosis by using advanced computer methods and existing medications.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11158753 on ClinicalTrials.gov |
What this research studies
Endometriosis causes chronic pain and infertility for millions of women, and current treatments often don't provide lasting relief. This work aims to discover new ways to treat endometriosis pain by looking at how existing drugs affect the disease at a molecular level. Researchers will use powerful computer tools to analyze vast amounts of genetic and molecular information from endometriosis patients. The most promising drug candidates, both single drugs and combinations, will then be tested in human cells and in animal models to see if they can reduce pain and improve symptoms.
Who could benefit from this research
Good fit: Patients with endometriosis who experience chronic pelvic pain, dysmenorrhea, dyspareunia, or infertility may ultimately benefit from this research.
Not a fit: Patients without endometriosis or those whose symptoms are well-managed by current treatments may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new and more effective drug options for women suffering from endometriosis, offering better pain relief and improved quality of life.
How similar studies have performed: While drug repurposing using computational methods is a growing field, the specific drug candidates identified and validated in this project are novel and untested for endometriosis.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SIROTA, MARINA — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: SIROTA, MARINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.