Finding new treatments for cognitive decline in older adults
Discovery of functionally selective dopamine ligands for age-related cognitive decline
['FUNDING_R01'] · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · NIH-11105966
This study is looking at how certain medications can help boost memory and thinking skills in older adults who are having trouble with these abilities as they age.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PENNSYLVANIA STATE UNIV HERSHEY MED CTR (nih funded) |
| Locations | 1 site (HERSHEY, UNITED STATES) |
| Trial ID | NIH-11105966 on ClinicalTrials.gov |
What this research studies
This research investigates how specific dopamine receptors can be targeted to improve cognitive functions, particularly in older adults experiencing memory decline. By exploring the effects of functionally selective dopamine ligands, the study aims to understand how these compounds can enhance working memory and other cognitive processes that deteriorate with age. The research employs a combination of laboratory experiments, behavioral assessments in animal models, and computational studies to identify promising drug candidates for treating age-related cognitive issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing cognitive decline or memory impairment.
Not a fit: Patients with cognitive decline due to non-age-related factors, such as traumatic brain injury or acute neurological disorders, may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new medications that significantly improve memory and cognitive function in older adults.
How similar studies have performed: Previous research has shown that targeting dopamine receptors can enhance cognitive functions, indicating a promising avenue for further exploration.
Where this research is happening
HERSHEY, UNITED STATES
- PENNSYLVANIA STATE UNIV HERSHEY MED CTR — HERSHEY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANG, YANG — PENNSYLVANIA STATE UNIV HERSHEY MED CTR
- Study coordinator: YANG, YANG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.