Finding new treatments for childhood tumors without clear genetic targets
Developing new therapeutic strategies for pediatric tumors that lack clinically actionable mutations
This study is looking for new ways to treat childhood tumors that don’t have specific genetic changes to target, using smart technology to find weaknesses in the tumors that could help develop better treatments beyond just chemotherapy and radiation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project ID | NIH-10914865 on NIH RePORTER |
What this research studies
This research focuses on developing innovative therapies for pediatric tumors that lack actionable genetic mutations. By utilizing advanced techniques like CRISPR and machine learning, the team aims to identify non-oncogene dependencies in these tumors, which can serve as potential drug targets. The approach involves analyzing large datasets from previous cancer studies alongside patient tumor data to pinpoint specific vulnerabilities in pediatric cancers. This could lead to more effective treatment options that go beyond traditional chemotherapy and radiation.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with tumors that do not have clinically actionable mutations.
Not a fit: Patients with tumors that have well-defined genetic mutations or those who are not pediatric patients may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new, targeted treatment options for children with tumors that currently have limited therapeutic strategies.
How similar studies have performed: Other research has shown promise in targeting non-oncogene dependencies in various cancers, indicating that this approach could be effective for pediatric tumors as well.
Where this research is happening
Memphis, United States
- St. Jude Children's Research Hospital — Memphis, United States (Active)
Researchers
- Principal investigator: Geeleher, Paul — St. Jude Children's Research Hospital
- Study coordinator: Geeleher, Paul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.