Finding new treatments for Alzheimer's disease by targeting STEP proteins
Fragment-Based Discovery of STEP Modulators in Alzheimer's Disease Administrative Supplement
This study is looking at a protein linked to Alzheimer's disease and aims to find new ways to help improve thinking and behavior in people with the condition by testing new compounds in mice.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11194608 on NIH RePORTER |
What this research studies
This research focuses on a protein called STriatal-Enriched tyrosine Phosphatase (STEP), which is found in neurons and is believed to play a role in Alzheimer's disease. The project aims to discover new compounds that can modulate STEP activity, potentially reversing cognitive and behavioral deficits associated with Alzheimer's. By using mouse models of Alzheimer's and other related disorders, the researchers will test the effectiveness of these new STEP modulators. Patients may benefit from this research if successful treatments are developed that improve cognitive function in Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related neurodegenerative disorders.
Not a fit: Patients with non-neurodegenerative conditions or those without cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve cognitive function and quality of life for patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in targeting STEP for cognitive improvement in animal models, indicating potential for success in this approach.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Tautz, Lutz — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Tautz, Lutz
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.