Finding new treatments for Alzheimer's disease by targeting a specific protein
Discovery of apoE4 modulators for Alzheimer’s disease therapy
['FUNDING_R01'] · MAYO CLINIC JACKSONVILLE · NIH-11099765
This study is looking for new ways to help people with Alzheimer's by finding small compounds that can lower the harmful apoE4 protein in the brain, which could help prevent the buildup of harmful plaques and tangles associated with the disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MAYO CLINIC JACKSONVILLE (nih funded) |
| Locations | 1 site (JACKSONVILLE, UNITED STATES) |
| Trial ID | NIH-11099765 on ClinicalTrials.gov |
What this research studies
This research focuses on Alzheimer's disease, particularly the role of the apolipoprotein E4 (apoE4) protein, which is linked to increased risk for the disease. The team is developing a high-throughput screening method to identify small molecules that can modulate apoE4 levels and reduce its harmful effects on brain cells. By using advanced techniques, they aim to discover compounds that can prevent the accumulation of amyloid plaques and tau tangles, which are characteristic of Alzheimer's. Patients may benefit from new therapeutic options that could slow down or prevent the progression of Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who carry the APOE4 allele and are at risk for developing Alzheimer's disease.
Not a fit: Patients without the APOE4 allele or those who do not have Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve the treatment and management of Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in targeting apoE4 for Alzheimer's treatment, indicating that this approach could be a viable path forward.
Where this research is happening
JACKSONVILLE, UNITED STATES
- MAYO CLINIC JACKSONVILLE — JACKSONVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LI, YONGHE — MAYO CLINIC JACKSONVILLE
- Study coordinator: LI, YONGHE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia