Finding new treatments for Alzheimer's disease by targeting a specific protein.
Official title: Fragment-based discovery of STEP modulators in Alzheimer's disease
Funded at Sanford Burnham Prebys Medical Discovery Institute · NIH-10871662 · Data updated 2026-11-12
This study is looking for new ways to help people with Alzheimer's by testing special compounds that can block a protein called STEP, which might improve thinking and behavior in those affected by the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | May 15, 2024 |
| Project end | April 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $2,835,382 |
| NIH project number | 1RF1AG087011-01 |
| Project ID | NIH-10871662 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related neurodegenerative disorders.
✕Less likely to help
Patients with non-neurodegenerative conditions or those without cognitive impairments may not benefit from this research.
What this research studies
This research focuses on a protein called STriatal-Enriched tyrosine Phosphatase (STEP), which is found in neurons and is believed to play a role in Alzheimer's disease. The project aims to discover new compounds that can inhibit STEP, potentially reversing cognitive and behavioral deficits associated with Alzheimer's and other neurodegenerative disorders. By using advanced techniques, including animal models, the researchers will evaluate the effectiveness of these compounds in restoring normal brain function. Patients may benefit from new therapeutic options that target STEP to improve their cognitive health.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that significantly improve cognitive function in patients with Alzheimer's disease.
How similar studies have gone: Previous research has shown promising results in targeting STEP for neurodegenerative diseases, indicating a potential for success in this novel approach.
Where this research is happening
-
Sanford Burnham Prebys Medical Discovery Institute
La Jolla, United States Active
Researchers
- Principal investigator: Tautz, Lutz — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Tautz, Lutz
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.