Finding new treatments for addiction using natural compounds
Behavior-based discovery of small-molecule modulators of neurochemical signaling pathways that underlie addiction
['FUNDING_R01'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11091511
This study is exploring how certain natural substances can help change brain signals related to addiction, using tiny worms to find new ways to treat addiction by focusing on specific brain pathways that control rewards and impulses.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11091511 on ClinicalTrials.gov |
What this research studies
This research investigates how small molecules can influence neurochemical pathways related to addiction. By using behavior-based screens on a microscopic animal called C. elegans, researchers aim to identify natural products that can modulate signaling in the nervous system. The focus is on a unique set of microbial metabolites that are typically inactive but can be activated by environmental changes. This innovative approach could lead to the discovery of new therapies for addiction by targeting specific neural circuits involved in reward and impulse control.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with addiction or substance use disorders.
Not a fit: Patients who do not have a history of addiction or substance use disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel treatments for addiction that are more effective than current options.
How similar studies have performed: Other research has shown promise in using natural products for therapeutic purposes, but this specific approach is relatively novel.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RINGSTAD, NIELS — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: RINGSTAD, NIELS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: addictive disorder