Finding new treatments for acute myeloid leukemia by targeting a specific protein.
Screening for Inhibitors of the Chromatin Reader SGF29
This study is looking at ways to treat acute myeloid leukemia (AML) by targeting a protein called SGF29, which helps cancer cells grow, to see if blocking it can stop the disease from getting worse.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-11168638 on NIH RePORTER |
What this research studies
This research focuses on acute myeloid leukemia (AML), a severe blood cancer with low survival rates. The team aims to identify therapies that can target common molecular pathways affected by various mutations in AML. By inhibiting a protein called SGF29, which plays a role in the activation of cancer-related genes, the researchers hope to block the growth of leukemia cells. The study employs various advanced techniques to explore how targeting SGF29 can lead to effective treatments for different subtypes of AML.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with acute myeloid leukemia, particularly those with specific genetic mutations.
Not a fit: Patients with other types of leukemia or those whose AML does not involve the targeted pathways may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, more effective treatments for a significant number of AML patients.
How similar studies have performed: Previous research has shown promise in targeting similar epigenetic regulators in cancer treatment, indicating potential for success in this approach.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Deshpande, Aniruddha J. — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Deshpande, Aniruddha J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.