Finding new treatment targets for liver disease by studying genetic variations in patients.
Discovery of novel therapeutic targets for NASH through deep phenotyping of human knockouts and mechanistic studies
['FUNDING_R01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-10849905
This study is looking at how our genes might affect the way nonalcoholic fatty liver disease (NAFLD) can get worse and turn into a more serious condition called non-alcoholic steatohepatitis (NASH), and it's for anyone interested in understanding more about their liver health and potential new treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10849905 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic factors contributing to the progression of nonalcoholic fatty liver disease (NAFLD) to non-alcoholic steatohepatitis (NASH), which is a significant cause of liver disease. By analyzing a large cohort of individuals, including those with unique genetic backgrounds, the study aims to identify novel genetic loci associated with these conditions. The researchers will utilize advanced genetic analysis techniques to explore the causal genes and biological mechanisms involved in disease risk. This approach may lead to the discovery of new therapeutic targets that could improve treatment options for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with nonalcoholic fatty liver disease or those with a family history of liver disease.
Not a fit: Patients with liver diseases caused by alcohol consumption or other non-genetic factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for patients suffering from liver diseases like NASH.
How similar studies have performed: Previous research has shown promise in identifying genetic factors related to liver diseases, suggesting that this approach could yield significant insights.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SALEHEEN, DANISH — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: SALEHEEN, DANISH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.