Finding new treatment targets for chronic neck pain using RNA sequencing.
Identifying novel therapeutic targets for chronic neck pain: RNA-sequencing in human painful atlanto-axial arthropathy
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-10912656
This study is looking at the causes of chronic neck pain, especially related to arthritis in a specific joint, by analyzing tissue samples from patients having surgery, to find out what makes the pain different from those with short-term pain, which could help in developing better treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10912656 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular mechanisms behind chronic neck pain, particularly focusing on the atlanto-axial joint, which is often affected by arthritis. By using RNA sequencing on tissue samples from patients undergoing surgery for chronic neck pain, the study aims to identify specific molecular drivers of pain. Additionally, it will compare these samples with those from patients experiencing acute pain to better understand the differences in pain signaling. This approach combines advanced genetic analysis with patient phenotyping to uncover potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing surgery for chronic neck pain related to the atlanto-axial joint.
Not a fit: Patients with neck pain not related to the atlanto-axial joint or those who do not require surgery may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that specifically address the underlying causes of chronic neck pain.
How similar studies have performed: While the approach of using RNA sequencing in pain research is gaining traction, this specific investigation into chronic neck pain and the atlanto-axial joint is relatively novel.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CURATOLO, MICHELE — UNIVERSITY OF WASHINGTON
- Study coordinator: CURATOLO, MICHELE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.