Finding new treatment targets for advanced melanoma
Identifying Therapeutic Targets for Stage III Melanoma
This study is looking at how melanoma cells grow and spread, especially focusing on a gene called RhoJ that helps tumors develop and get the blood supply they need; by testing new treatments in specially designed mice, the researchers hope to find ways to stop melanoma from invading other areas and to block its access to lymphatic vessels.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10745698 on NIH RePORTER |
What this research studies
This research investigates how melanoma cells progress and spread, focusing on a gene called RhoJ that plays a crucial role in tumor growth and the formation of blood vessels that feed tumors. By studying genetically engineered mouse models, the researchers aim to identify therapeutic agents that can block melanoma invasion and prevent tumor cells from accessing lymphatic vessels. The approach includes using small molecules to inhibit RhoJ signaling, which has shown promise in stopping tumor growth and vessel formation in preliminary studies.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with Stage III melanoma who are seeking innovative treatment options.
Not a fit: Patients with early-stage melanoma or those who have not been diagnosed with melanoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve outcomes for patients with advanced melanoma.
How similar studies have performed: Previous research has shown success in targeting similar pathways in melanoma, suggesting that this approach may yield promising results.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Ganesan, Anand K — University of California-Irvine
- Study coordinator: Ganesan, Anand K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.