Finding new treatment targets for a common kidney disease
Identification of new therapeutic targets for ADPKD
This study is looking for new ways to treat autosomal-dominant polycystic kidney disease (ADPKD) by exploring certain proteins that might be causing kidney cysts to grow, so we can find better treatments for people living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10861797 on NIH RePORTER |
What this research studies
This research focuses on identifying new therapeutic targets for autosomal-dominant polycystic kidney disease (ADPKD), a condition affecting millions worldwide. The team will investigate the role of various kinases, which are proteins that help regulate cellular functions, in the growth of cysts associated with ADPKD. By using advanced screening techniques, they aim to discover kinases that are more active in diseased kidneys compared to healthy ones, potentially leading to new treatment options. The research involves collaboration with experts and utilizes innovative methodologies to enhance understanding of the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autosomal-dominant polycystic kidney disease.
Not a fit: Patients with other forms of kidney disease or those without a diagnosis of ADPKD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new therapies that effectively slow or stop the progression of ADPKD.
How similar studies have performed: Previous research has shown promise in targeting kinases to slow cyst growth in animal models, indicating potential for success in this novel approach.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Skolnik, Edward Y — New York University School of Medicine
- Study coordinator: Skolnik, Edward Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.