Finding new targets for treating opioid addiction
Discovery of novel pharmacotherapeutic targets for opioid addiction
This study is looking at how oxycodone addiction works in the brain, especially what happens when someone is tempted to relapse, to find new ways to help people stay off opioids.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project ID | NIH-10806256 on NIH RePORTER |
What this research studies
This research investigates the cellular and molecular mechanisms behind opioid addiction, specifically focusing on oxycodone. Using advanced techniques, the study aims to identify genes related to relapse in the brain by tagging activated neurons in response to cues. The researchers will analyze brain-wide data to understand how these genes contribute to addiction and may serve as targets for new medications to prevent relapse. This approach combines innovative imaging and genetic analysis to uncover potential therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals struggling with opioid addiction or those who have experienced relapse.
Not a fit: Patients who are not affected by opioid addiction or those who have not used opioids may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new medications that help prevent relapse in individuals recovering from opioid addiction.
How similar studies have performed: Other research has shown promise in identifying genetic targets for addiction treatment, suggesting that this approach could yield valuable insights.
Where this research is happening
Charleston, United States
- Medical University of South Carolina — Charleston, United States (Active)
Researchers
- Principal investigator: Smith, Alexander Wanless — Medical University of South Carolina
- Study coordinator: Smith, Alexander Wanless
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.