Finding New Small Proteins in Our Genes
The Discovery of Human Peptide Encoding Genes
This research helps us find and understand tiny proteins in our bodies that were previously unknown, which could lead to new ways to develop medicines.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Salk Institute for Biological Studies NIH-funded |
| Lab location | 1 site (La Jolla, UNITED STATES) |
| Project ID | NIH-11111415 on NIH RePORTER |
What this research studies
Our bodies are made up of many proteins, and while we've mapped most of the larger ones, we've recently found thousands of tiny, previously unknown proteins called microproteins. This project aims to understand what these microproteins do, whether they have important jobs in our cells, and if they can travel outside of cells to send messages. We are also exploring if we can create special tools, like small molecules, to control how these microproteins work, which could open doors for new treatments.
Who could benefit from this research
Good fit: This foundational research does not involve direct patient participation at this stage.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this early-stage discovery research.
Why it matters
Potential benefit: If successful, this work could lead to the discovery of new biological pathways and targets for developing innovative medicines for various diseases.
How similar studies have performed: While the existence of microproteins is a recent discovery, this project builds on new technologies and initial findings that suggest their widespread presence and potential importance.
Where this research is happening
La Jolla, UNITED STATES
- Salk Institute for Biological Studies — La Jolla, United States (Active)
Researchers
- Principal investigator: Saghatelian, Alan — Salk Institute for Biological Studies
- Study coordinator: Saghatelian, Alan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.