Finding new small molecules to help restore normal heart rhythm in atrial fibrillation
Discovery of small molecule regulators of atrial cardiomyocyte action potential duration to restore normal cardiac rhythm in atrial fibrillation
This study is looking for new ways to help people with atrial fibrillation by finding tiny molecules that can help control the heart's electrical activity, using special imaging techniques on heart cells made from stem cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sanford Burnham Prebys Medical Discovery Institute NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10843928 on NIH RePORTER |
What this research studies
This research focuses on atrial fibrillation (AF), a common heart rhythm disorder affecting millions. It aims to discover small molecules that can regulate the electrical activity of heart cells, specifically targeting the action potential duration in atrial cardiomyocytes. Using advanced imaging techniques, the researchers will screen human heart cells derived from stem cells to identify potential new treatments. The goal is to improve the effectiveness of AF treatments and reduce complications associated with the condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with atrial fibrillation who are seeking better treatment options.
Not a fit: Patients without atrial fibrillation or those with other unrelated heart conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for atrial fibrillation, improving patient outcomes and quality of life.
How similar studies have performed: Previous research has shown promise in using similar high-throughput screening methods to identify effective treatments for cardiac arrhythmias.
Where this research is happening
La Jolla, United States
- Sanford Burnham Prebys Medical Discovery Institute — La Jolla, United States (Active)
Researchers
- Principal investigator: Colas, Alexandre Romain — Sanford Burnham Prebys Medical Discovery Institute
- Study coordinator: Colas, Alexandre Romain
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.