Finding new regulators that organize the genome
High-throughput Discovery of Novel Genome Organization Regulators
This study is looking at how a protein called CTCF helps keep our genes organized in cells, using smart computer tools to find new factors that might affect how our genes work, which could help us understand more about health and diseases.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10777403 on NIH RePORTER |
What this research studies
This research investigates how certain proteins, particularly CTCF, help organize the genome within cells. By using advanced deep learning techniques, the researchers aim to predict and identify new factors that influence genome structure and function. They will analyze large genomic datasets to discover these regulators and validate their findings through experimental studies. This approach could enhance our understanding of genetic regulation and its implications for health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or diseases linked to genome organization abnormalities.
Not a fit: Patients with conditions unrelated to genetic regulation or genome organization may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into genetic regulation that may improve treatments for various diseases.
How similar studies have performed: Other research has shown promise in using deep learning for genomic studies, indicating that this approach could yield significant insights.
Where this research is happening
Cambridge, United States
- Broad Institute, INC. — Cambridge, United States (Active)
Researchers
- Principal investigator: Xia, Bo — Broad Institute, INC.
- Study coordinator: Xia, Bo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.