Finding new regulators that organize the genome
Official title: High-throughput Discovery of Novel Genome Organization Regulators
Funded at Broad Institute, INC. · NIH-10777403 · Data updated 2026-11-12
This study is looking at how a protein called CTCF helps keep our genes organized in cells, using smart computer tools to find new factors that might affect how our genes work, which could help us understand more about health and diseases.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | September 20, 2023 |
| Project end | September 19, 2025 |
| Funding year | 2023 |
| Award (this year) | $292,728 |
| NIH project number | 1R03OD036495-01 |
| Project ID | NIH-10777403 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic disorders or diseases linked to genome organization abnormalities.
✕Less likely to help
Patients with conditions unrelated to genetic regulation or genome organization may not benefit from this research.
What this research studies
This research investigates how certain proteins, particularly CTCF, help organize the genome within cells. By using advanced deep learning techniques, the researchers aim to predict and identify new factors that influence genome structure and function. They will analyze large genomic datasets to discover these regulators and validate their findings through experimental studies. This approach could enhance our understanding of genetic regulation and its implications for health and disease.
Why it matters
Potential benefit: If successful, this research could lead to new insights into genetic regulation that may improve treatments for various diseases.
How similar studies have gone: Other research has shown promise in using deep learning for genomic studies, indicating that this approach could yield significant insights.
Where this research is happening
-
Broad Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Xia, Bo — Broad Institute, INC.
- Study coordinator: Xia, Bo
Related research
Other NIH-funded projects on the same topics.
-
Broad-Color: A Center to Accelerate All of Us Genomics
A national effort to speed up personalized medicine by expanding genomic data and clinical insight for All of Us participants.
-
Common Fund data knowledge center to make big data insights easy to use
A project to make NIH Common Fund datasets easy to find, understand, and use for researchers by turning them into trusted, clearly explained knowledge that supports big data discoveries.
-
Massive-scale genomic risk assessment to inform precision medicine for diabetes
A large study aims to map how genetic differences influence different forms of diabetes to guide personalized care.
-
Massive-scale genetic risk profiling to guide personalized diabetes care
A large NIH-funded project will study how many diabetes-related genetic variants influence risk across diverse populations to help tailor prevention and treatment.
-
Asian Bipolar Genetics Network study
This project studies the genetics of bipolar disorder in East and South Asian people to better understand risk factors and how they may affect diagnosis and care.
-
Broad-Color: A Genomic Center to Accelerate All of Us for Better Health
A national genomic resource project will expand and speed up how researchers use genetic data from All of Us participants to improve understanding, diagnosis, and treatment of human diseases.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.