Finding new proteins from Bordetella pertussis to improve vaccines
Identification of novel immunogenic proteins from Bordetella pertussis
This study is looking for new proteins from the whooping cough bacteria to help make better vaccines that can protect you from getting sick and stop the spread of the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-11082525 on NIH RePORTER |
What this research studies
This research aims to identify novel immunogenic proteins from the Bordetella pertussis bacteria, which causes whooping cough. The study will utilize advanced techniques such as mass spectrometry and bioinformatics to analyze the proteins expressed by circulating strains of the bacteria. By understanding which proteins elicit strong immune responses, the research seeks to enhance the effectiveness of acellular vaccines, which currently do not prevent nasal colonization or transmission of the bacteria. The goal is to develop a more robust vaccine that can provide better protection against pertussis outbreaks.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk of pertussis infection, including infants, children, and adults who have not been fully vaccinated.
Not a fit: Patients who have already received the current acellular pertussis vaccine and are not at risk for pertussis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective vaccines against whooping cough, reducing the incidence of outbreaks.
How similar studies have performed: Other research has shown promise in identifying new vaccine targets using similar approaches, indicating potential for success in this area.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Dubey, Purnima — Ohio State University
- Study coordinator: Dubey, Purnima
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.