Finding new non-opioid pain relief options
Discovery of PSD95 protein-protein interaction inhibitors as novel non-opioid analgesics
This study is looking at new ways to help people with chronic nerve pain by creating safer medications that don’t rely on opioids, focusing on how certain brain proteins work together to signal pain, and it hopes to offer better pain relief with fewer side effects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Anagin NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project ID | NIH-10802201 on NIH RePORTER |
What this research studies
This research focuses on developing new medications to effectively treat chronic neuropathic pain without the risks associated with opioids. It investigates how certain proteins in the brain interact and contribute to pain signaling, specifically targeting the PSD95 protein complex. By using small molecules that disrupt these protein interactions, the research aims to create safer and more effective analgesics. Patients may benefit from these new treatments that could provide pain relief with fewer side effects compared to current options.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic neuropathic pain who are seeking alternative pain management options.
Not a fit: Patients with acute pain conditions or those who do not experience neuropathic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative non-opioid medications that effectively manage chronic pain.
How similar studies have performed: Previous research has shown promise in targeting similar protein interactions for pain relief, indicating a potential for success in this novel approach.
Where this research is happening
Indianapolis, United States
- Anagin — Indianapolis, United States (Active)
Researchers
- Principal investigator: Florio, Stephanie K — Anagin
- Study coordinator: Florio, Stephanie K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.