Finding new molecules to target leukemia cells
Cheminformatics-based identification of leukemia-targeting molecules
['FUNDING_R21'] · RICE UNIVERSITY · NIH-11045716
This study is looking at how certain cancer-fighting drugs can target and kill leukemia cells while protecting healthy cells, with the hope of finding better treatment options for older adults with acute myeloid leukemia.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RICE UNIVERSITY (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11045716 on ClinicalTrials.gov |
What this research studies
This research focuses on acute myeloid leukemia (AML), a severe form of blood cancer that primarily affects older adults. The team is investigating how leukemia cells respond to mitochondrial toxins, which could lead to new treatment options. By using advanced bioinformatics and laboratory techniques, they aim to identify combinations of drugs that selectively kill cancer cells while sparing healthy cells. This approach could improve outcomes for patients who currently have limited treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with acute myeloid leukemia, particularly those over the age of 65.
Not a fit: Patients with other types of leukemia or those who are not diagnosed with acute myeloid leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and targeted therapies for patients with acute myeloid leukemia.
How similar studies have performed: Previous research has shown promising results using mitochondrial-targeting therapies in cancer treatment, suggesting potential for success in this novel approach.
Where this research is happening
HOUSTON, UNITED STATES
- RICE UNIVERSITY — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIRIENKO, NATASHA — RICE UNIVERSITY
- Study coordinator: KIRIENKO, NATASHA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.