Finding new long-lasting drugs to prevent malaria
Discovery of long-acting, chemoprotective antimalarial compounds
This study is looking for new medicines that can help protect people from malaria for a long time by testing a huge number of different compounds to find ones that stop the malaria parasites from growing in the liver.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10798218 on NIH RePORTER |
What this research studies
This research focuses on discovering new antimalarial drugs that can provide long-lasting protection against malaria. By screening over 500,000 compounds, the team aims to identify those that effectively inhibit the development of malaria parasites in the liver. The approach includes testing various compounds through multiple assays to determine their effectiveness and safety. Promising candidates will undergo further optimization and testing in animal models to evaluate their potential as preventive treatments for malaria.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living in or traveling to malaria-endemic regions who may benefit from improved malaria prevention strategies.
Not a fit: Patients who are not at risk of malaria or those who have already been effectively treated with existing antimalarial medications may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new antimalarial drugs that offer better protection and treatment options for patients at risk of malaria.
How similar studies have performed: Other research has shown success in developing antimalarial drugs through similar high-throughput screening approaches, indicating a promising avenue for new treatments.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Winzeler, Elizabeth a — University of California, San Diego
- Study coordinator: Winzeler, Elizabeth a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.