Finding new genes that increase the risk of knee osteoarthritis
Identifying novel osteoarthritis risk genes using GWAS, chondrocyte genomics, and genome editing
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10906863
This study is looking at how our genes might play a role in knee osteoarthritis, which could help find new ways to treat this common condition and improve care for people who have it.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10906863 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic factors that contribute to knee osteoarthritis (OA), a common condition that currently has limited treatment options. By using advanced techniques like genome-wide association studies (GWAS) and genome editing, the team aims to identify specific genetic variations that increase the risk of developing OA. The research will focus on understanding how these genetic factors affect chondrocytes, the cells responsible for cartilage health, and how they respond to cartilage degradation. Ultimately, this work seeks to uncover new targets for potential therapies that could improve treatment options for patients with knee OA.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for knee osteoarthritis, particularly those with a family history of the condition or early signs of cartilage degradation.
Not a fit: Patients who do not have knee osteoarthritis or are not at risk for developing it may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new genetic insights and therapeutic targets for treating knee osteoarthritis, potentially improving patient outcomes.
How similar studies have performed: Previous research using similar genetic approaches has shown promise in identifying risk factors for other conditions, suggesting potential for success in this area as well.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PHANSTIEL, DOUGLAS H. — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: PHANSTIEL, DOUGLAS H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.