Finding new genes that affect bone cell activity
Identification of Novel Genes Impacting Osteoblast Activity
This study is looking at how our genes affect the cells that build bones, especially in kids, to find out why some people might have weaker bones or conditions like osteoporosis, so we can better understand and improve bone health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10868668 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that influence the activity of osteoblasts, the cells responsible for bone formation. By utilizing advanced techniques like ATAC sequencing, the study aims to identify novel genes that may play a role in bone density and strength, particularly in children. The research focuses on understanding how these genetic variations can lead to conditions like osteoporosis and low bone mineral density. Patients may be monitored over time to assess the impact of these genetic factors on bone health.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under 11 years old who may be at risk for bone density issues or related conditions.
Not a fit: Patients who are older than 11 years or those without any bone health concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for improving bone health and preventing fractures in children.
How similar studies have performed: Previous research has successfully identified genetic factors affecting bone density, suggesting that this approach may yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Ackert-Bicknell, Cheryl Lynne — University of Colorado Denver
- Study coordinator: Ackert-Bicknell, Cheryl Lynne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.