Finding new drugs to treat a fungal infection called coccidioidomycosis
Official title: Screening Repurposing Libraries for the Identification of Drugs with Novel anti-Coccidioidal Activity
Funded at University of Texas San Antonio · NIH-11004656 · Data updated 2026-11-12
This study is looking for new and better medicines to help people with coccidioidomycosis, a fungal infection, by testing existing drugs to see how well they can stop the fungus from growing.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas San Antonio NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | January 1, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $271,400 |
| NIH project number | 5U19AI166761-04 |
| Project ID | NIH-11004656 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with coccidioidomycosis or those at high risk of infection.
✕Less likely to help
Patients with non-fungal infections or those who do not have coccidioidomycosis may not benefit from this research.
What this research studies
This research focuses on coccidioidomycosis, a fungal infection caused by Coccidioides posadasii and Coccidioides immitis, which affects approximately 150,000 people in the U.S. each year. The study aims to identify new therapeutic drugs by screening existing drug libraries for their effectiveness against the parasitic form of the fungus. Researchers will utilize a novel methodology called fungal cytological profiling (FCP) to assess how these drugs affect the growth and development of the fungus. This approach is designed to find safer and more effective treatments for patients suffering from this infection.
Why it matters
Potential benefit: If successful, this research could lead to the development of safer and more effective treatments for coccidioidomycosis.
How similar studies have gone: Previous research has shown promise in repurposing existing drugs for fungal infections, indicating potential success for this approach.
Where this research is happening
-
University of Texas San Antonio
San Antonio, United States Active
Researchers
- Principal investigator: Yu, Jieh-Juen — University of Texas San Antonio
- Study coordinator: Yu, Jieh-Juen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.