Finding new drugs to target a brain enzyme linked to Alzheimer's disease
Identification of CNS-Penetrant Tryptophan 2,3-Dioxygenase Degrading Ligands
This study is looking at a special enzyme that affects brain health and is connected to Alzheimer's disease, and the researchers want to find new ways to block this enzyme to help improve symptoms of depression and brain issues for people with Alzheimer's and similar conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project ID | NIH-10690026 on NIH RePORTER |
What this research studies
This research investigates the role of tryptophan 2,3-dioxygenase (TDO), an enzyme that affects brain health and is linked to neurodegenerative diseases like Alzheimer's. The team aims to identify new compounds that can inhibit TDO's activity, which may help reduce symptoms of depression and brain degeneration. By understanding how TDO functions and its binding sites, the researchers hope to develop innovative treatments that could improve the lives of patients with Alzheimer's and related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related neurodegenerative conditions.
Not a fit: Patients with non-neurodegenerative conditions or those not diagnosed with Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that slow down or prevent the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in targeting similar pathways in neurodegenerative diseases, suggesting potential for success in this innovative approach.
Where this research is happening
West Lafayette, United States
- Purdue University — West Lafayette, United States (Active)
Researchers
- Principal investigator: Altman, Ryan a — Purdue University
- Study coordinator: Altman, Ryan a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.