Finding new drugs to inhibit a specific protein involved in cancer
Discovery of small molecule inhibitors for protein N-terminal acetyltransferase D
['FUNDING_R01'] · PURDUE UNIVERSITY · NIH-10988319
This study is looking for new medicines that can block a protein called NatD, which is connected to the growth of certain cancers like lung and colorectal cancer, to help create better treatments for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PURDUE UNIVERSITY (nih funded) |
| Locations | 1 site (WEST LAFAYETTE, UNITED STATES) |
| Trial ID | NIH-10988319 on ClinicalTrials.gov |
What this research studies
This research focuses on discovering small molecule inhibitors for protein N-terminal acetyltransferase D (NatD), which is linked to cancer progression, particularly in lung and colorectal cancers. The team will utilize high-throughput screening methods to test 400,000 different compounds to identify those that can effectively inhibit NatD's activity. By understanding how NatD functions in cancer, the research aims to develop targeted therapies that could improve treatment outcomes for patients. The project is expected to provide insights into the role of NatD in cancer biology and pave the way for new therapeutic options.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with lung or colorectal cancer who may benefit from novel therapeutic approaches.
Not a fit: Patients with cancers unrelated to the mechanisms of NatD or those who are not currently undergoing treatment for lung or colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new cancer treatments that specifically target NatD, potentially improving survival rates and quality of life for patients with lung and colorectal cancers.
How similar studies have performed: While the specific approach of targeting NatD is novel, similar strategies targeting other acetyltransferases have shown promise in cancer treatment.
Where this research is happening
WEST LAFAYETTE, UNITED STATES
- PURDUE UNIVERSITY — WEST LAFAYETTE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUANG, RONG — PURDUE UNIVERSITY
- Study coordinator: HUANG, RONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.