Finding new drugs to help treat substance use disorders
Official title: New Technologies for Accelerating the Discovery and Characterization of Neuroactives that Address Substance Use Disorders
Funded at University of California, San Francisco · NIH-11036246 · Data updated 2026-11-12
This study is looking for new medications to help people with opioid addiction by finding better ways to manage pain and reduce addictive behaviors, which could lead to more effective treatments for those struggling with substance use disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | April 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $484,500 |
| NIH project number | 5DP1DA058350-03 |
| Project ID | NIH-11036246 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals struggling with substance use disorders, particularly those affected by opioid addiction.
✕Less likely to help
Patients who are not currently experiencing substance use disorders or those who have not responded to previous treatments may not benefit from this research.
What this research studies
This research focuses on developing new medications to address substance use disorders, particularly those related to opioid addiction. It aims to discover alternative pain management options, behavior-modifying drugs, and new antidotes for drug overdoses. By utilizing advanced screening techniques, the research seeks to identify small molecules that can effectively modify addictive behaviors in animal models. This could lead to innovative treatments that clinicians can use to help patients struggling with addiction.
Why it matters
Potential benefit: If successful, this research could provide new therapeutic options for patients suffering from substance use disorders, potentially saving lives and improving treatment outcomes.
How similar studies have gone: Other research has shown promise in developing new pharmacotherapies for addiction, indicating that this approach could lead to significant advancements in treatment.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Mccarroll, Matthew N — University of California, San Francisco
- Study coordinator: Mccarroll, Matthew N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.