Finding new drug combinations to treat Mycobacterium abscessus lung infections
Discovery of novel lead-target pairs and identification of all-oral bactericidal drug regimens for Mycobacterium abscessus lung disease
This study is working on finding better oral medications to help people with lung infections caused by a tough bacteria called Mycobacterium abscessus, by exploring new drug combinations and understanding how the bacteria resist treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hackensack University Medical Center NIH-funded |
| Lab location | 1 site (Hackensack, United States) |
| Project ID | NIH-11123248 on NIH RePORTER |
What this research studies
This research focuses on developing effective oral drug regimens to combat Mycobacterium abscessus (Mab), a bacterium responsible for increasing cases of lung infections. The team is leveraging past research and advanced compounds to identify novel lead-target pairs that can enhance treatment efficacy. By studying the mechanisms of drug resistance and testing combinations of existing antibiotics, the research aims to create more potent and effective treatment options for patients suffering from this challenging infection.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Mycobacterium abscessus lung disease who have not responded well to current antibiotic treatments.
Not a fit: Patients with lung infections caused by other types of bacteria or those who do not have Mycobacterium abscessus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective oral treatments for patients with Mycobacterium abscessus lung disease, improving their health outcomes.
How similar studies have performed: Previous research has shown promise in developing effective treatments for similar bacterial infections, indicating that this approach could yield beneficial results.
Where this research is happening
Hackensack, United States
- Hackensack University Medical Center — Hackensack, United States (Active)
Researchers
- Principal investigator: Dick, Thomas — Hackensack University Medical Center
- Study coordinator: Dick, Thomas
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.