Finding new drug combinations to treat glioblastoma
Connectivity mapping identified novel combination therapy for glioblastoma
This study is looking at new ways to treat glioblastoma, a tough type of brain cancer, by testing a drug called PCI-24781 alongside regular treatments to see if it can help shrink tumors and improve patient outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10919216 on NIH RePORTER |
What this research studies
This research investigates new combination therapies for glioblastoma, a type of brain cancer with limited treatment options. By utilizing a method called Connectivity Map, researchers analyze genetic profiles of glioblastoma samples to identify promising drug candidates. The focus is on a specific drug, PCI-24781, which targets certain proteins involved in cancer cell survival and has shown potential in preliminary studies to reduce tumor size. Patients may be treated with this drug in combination with standard therapies to improve outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with glioblastoma who have undergone initial treatment.
Not a fit: Patients with other types of brain tumors or those who have not been diagnosed with glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment options for patients with glioblastoma, potentially improving survival rates.
How similar studies have performed: Previous research using similar approaches has shown promise in identifying effective therapies for glioblastoma, but this specific combination therapy is novel.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Shonka, Nicole — University of Nebraska Medical Center
- Study coordinator: Shonka, Nicole
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.