Finding new compounds to treat Alzheimer's and other diseases
Official title: Computational approaches to discover ligands with new chemotypes and functional properties
Funded at University of Southern California · NIH-10842818 · Data updated 2026-11-12
This study is working on finding new molecules that could help treat conditions like Alzheimer's, cancer, and pain by using smart computer methods to search through many different chemicals, and then testing the best ones to make sure they are safe and effective for people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | September 22, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $69,167 |
| NIH project number | 1R35GM153437-01 |
| Project ID | NIH-10842818 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related conditions, as well as those suffering from pain or substance abuse issues.
✕Less likely to help
Patients with conditions unrelated to Alzheimer's disease, cancer, or pain may not benefit from this research.
What this research studies
This research focuses on developing advanced computational methods to discover new ligands, which are molecules that can bind to specific targets in the body, potentially leading to new treatments for conditions like Alzheimer's disease, cancer, and pain. By combining structure-based and data-driven approaches, the team aims to create a scalable platform that can efficiently screen vast chemical libraries for promising candidates. The project will also validate these findings through experimental methods, ensuring that the discovered ligands are effective and safe for clinical use.
Why it matters
Potential benefit: If successful, this research could lead to the development of new and more effective treatments for Alzheimer's disease and other serious conditions.
How similar studies have gone: Previous research has shown promise in using computational methods for drug discovery, indicating that this approach could yield significant advancements in treatment options.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Katritch, Vsevolod — University of Southern California
- Study coordinator: Katritch, Vsevolod
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.