Finding new compounds to treat Alzheimer's and other diseases
Computational approaches to discover ligands with new chemotypes and functional properties
This study is working on finding new molecules that could help treat conditions like Alzheimer's, cancer, and pain by using smart computer methods to search through many different chemicals, and then testing the best ones to make sure they are safe and effective for people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10842818 on NIH RePORTER |
What this research studies
This research focuses on developing advanced computational methods to discover new ligands, which are molecules that can bind to specific targets in the body, potentially leading to new treatments for conditions like Alzheimer's disease, cancer, and pain. By combining structure-based and data-driven approaches, the team aims to create a scalable platform that can efficiently screen vast chemical libraries for promising candidates. The project will also validate these findings through experimental methods, ensuring that the discovered ligands are effective and safe for clinical use.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related conditions, as well as those suffering from pain or substance abuse issues.
Not a fit: Patients with conditions unrelated to Alzheimer's disease, cancer, or pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new and more effective treatments for Alzheimer's disease and other serious conditions.
How similar studies have performed: Previous research has shown promise in using computational methods for drug discovery, indicating that this approach could yield significant advancements in treatment options.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Katritch, Vsevolod — University of Southern California
- Study coordinator: Katritch, Vsevolod
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.