Finding new biomarkers for portopulmonary hypertension
Official title: Biomarker Discovery in Portopulmonary Hypertension
Funded at University of Cincinnati · NIH-11071981 · Data updated 2026-11-12
This study is looking for new ways to diagnose and understand portopulmonary hypertension in people with liver disease, so we can better predict how serious the condition is and help improve treatment for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Cincinnati NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | April 21, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $204,228 |
| NIH project number | 5K23HL164971-03 |
| Project ID | NIH-11071981 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with portopulmonary hypertension who also have underlying liver disease.
✕Less likely to help
Patients without liver disease or those not diagnosed with portopulmonary hypertension may not benefit from this research.
What this research studies
This research focuses on portopulmonary hypertension (PoPH), a severe condition affecting patients with liver disease. It aims to identify new biomarkers that can accurately diagnose and predict the severity of PoPH, which is currently challenging due to the limitations of existing markers. By using advanced techniques like next-generation sequencing, the study will analyze liver tissue and validate findings through a biorepository. This approach seeks to enhance our understanding of the disease mechanisms and improve patient outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and better treatment strategies for patients with portopulmonary hypertension.
How similar studies have gone: Previous research has shown promise in biomarker discovery for other forms of pulmonary hypertension, suggesting potential for success in this novel approach.
Where this research is happening
-
University of Cincinnati
Cincinnati, United States Active
Researchers
- Principal investigator: Jose, Arun — University of Cincinnati
- Study coordinator: Jose, Arun
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.