Finding new biomarkers for Parkinson's disease using nerve cells from patients
Official title: Biomarker discovery for parkinsonian diseases in extracellular vesicles from iPSC-derived neurons
Funded at University of California Los Angeles · NIH-11090272 · Data updated 2026-11-12
This study is looking for new signs of Parkinson's disease by examining tiny particles released from nerve cells made from patients' own stem cells, hoping to find better ways to diagnose and treat the condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $180,717 |
| NIH project number | 3RF1NS126406-01A1S1 |
| Project ID | NIH-11090272 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Parkinson's disease or atypical parkinsonian syndromes.
✕Less likely to help
Patients with other unrelated neurological disorders or those without a diagnosis of parkinsonian diseases may not benefit from this research.
What this research studies
This research investigates the discovery of biomarkers for Parkinson's disease and related conditions by analyzing extracellular vesicles derived from patient-specific neurons created from induced pluripotent stem cells (iPSCs). The approach involves isolating these vesicles from the culture media of neurons to identify potential biomarkers that could improve diagnosis and treatment. By comparing samples from patients with parkinsonian diseases and healthy controls, the research aims to uncover novel indicators that can enhance understanding and management of these complex neurodegenerative disorders.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and better treatment options for patients with Parkinson's disease and related conditions.
How similar studies have gone: Previous research has shown promise in using similar proteomics-based approaches for biomarker discovery, indicating potential for success in this novel application.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Bitan, Gal — University of California Los Angeles
- Study coordinator: Bitan, Gal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.