Finding new biomarkers for early diagnosis of Alzheimer's disease
DiLeu-enabled multiplexed quantitation for biomarker discovery and validation in Alzheimer’s disease
This study is looking for new ways to spot Alzheimer's disease early by testing blood and spinal fluid samples, making it easier and less invasive for people to get diagnosed and track how the disease is changing over time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11076823 on NIH RePORTER |
What this research studies
This research focuses on identifying and validating biomarkers that can help diagnose Alzheimer's disease (AD) at an early stage. By using advanced mass spectrometry techniques, the study aims to analyze both cerebrospinal fluid and serum samples to discover reliable indicators of AD. This approach is less invasive than traditional methods and seeks to establish a correlation between blood and cerebrospinal fluid biomarkers. The ultimate goal is to improve early diagnosis and monitor disease progression effectively.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults over 21 years old who may be experiencing early signs of cognitive impairment or are at risk for Alzheimer's disease.
Not a fit: Patients with advanced Alzheimer's disease or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses of Alzheimer's disease, allowing for timely interventions.
How similar studies have performed: Previous research has shown promise in using blood-based biomarkers for Alzheimer's diagnosis, suggesting that this approach could yield valuable insights.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Li, Lingjun — University of Wisconsin-Madison
- Study coordinator: Li, Lingjun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.