Finding new antiviral drugs to fight influenza viruses
High-throughput assays and small-molecule discovery of antiviral candidates targeting influenza hemagglutinin
This study is looking for new medicines that can stop the flu virus from infecting people by targeting a key part of the virus, and if successful, these new treatments could help patients who get the flu.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Scripps Research Institute, the NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10830288 on NIH RePORTER |
What this research studies
This research focuses on discovering new antiviral candidates that can effectively target the influenza virus, specifically its hemagglutinin protein, which is crucial for the virus's ability to infect cells. By utilizing advanced high-throughput assays, the team aims to identify small molecules that can block the virus from entering host cells. The approach leverages recent structural insights into the virus's vulnerabilities, allowing for the design of targeted therapies that could be broadly effective against various strains of influenza. Patients may benefit from these new antiviral drugs if they are developed successfully.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk for influenza infections, such as those with compromised immune systems or chronic health conditions.
Not a fit: Patients who are not at risk for influenza or those who have already been vaccinated may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective antiviral medications that prevent influenza infections and reduce the severity of illness.
How similar studies have performed: Other research has shown promise in targeting similar viral proteins, indicating that this approach could lead to significant advancements in antiviral therapies.
Where this research is happening
La Jolla, United States
- Scripps Research Institute, the — La Jolla, United States (Active)
Researchers
- Principal investigator: Wilson, Ian a — Scripps Research Institute, the
- Study coordinator: Wilson, Ian a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.