Finding new antimicrobial peptides from soil bacteria.
Official title: Identification and Biosynthesis of Dehydrated Nonribosomal Peptides from Streptomyces
Funded at Univ of North Carolina Chapel Hill · NIH-11115555 · Data updated 2026-11-12
This study is looking for new natural compounds from soil bacteria that can help fight infections, especially those that are hard to treat because they resist antibiotics, and it's for anyone interested in better ways to tackle these tough germs.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | June 1, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $78,040 |
| NIH project number | 5F32GM154449-02 |
| Project ID | NIH-11115555 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from infections caused by antimicrobial-resistant bacteria.
✕Less likely to help
Patients with infections that are not caused by antimicrobial-resistant microorganisms may not benefit from this research.
What this research studies
This research focuses on identifying and developing new nonribosomal peptides, which are natural compounds that can act as antimicrobials. The team will explore specific peptides that are derived from soil bacteria, particularly Streptomyces, and investigate their biosynthetic pathways. By utilizing advanced genome mining techniques, they aim to uncover the structures and functions of these peptides, which could lead to new treatments for infections caused by antimicrobial-resistant microorganisms.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel antimicrobial therapies that effectively combat resistant infections.
How similar studies have gone: Previous research has shown promise in identifying bioactive nonribosomal peptides, indicating that this approach could lead to significant advancements in antimicrobial therapy.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Mull, Ryan Wyatt — Univ of North Carolina Chapel Hill
- Study coordinator: Mull, Ryan Wyatt
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.