Finding new antimicrobial peptides from soil bacteria.
Identification and Biosynthesis of Dehydrated Nonribosomal Peptides from Streptomyces
['FUNDING_FELLOWSHIP'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-11115555
This study is looking for new natural compounds from soil bacteria that can help fight infections, especially those that are hard to treat because they resist antibiotics, and it's for anyone interested in better ways to tackle these tough germs.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-11115555 on ClinicalTrials.gov |
What this research studies
This research focuses on identifying and developing new nonribosomal peptides, which are natural compounds that can act as antimicrobials. The team will explore specific peptides that are derived from soil bacteria, particularly Streptomyces, and investigate their biosynthetic pathways. By utilizing advanced genome mining techniques, they aim to uncover the structures and functions of these peptides, which could lead to new treatments for infections caused by antimicrobial-resistant microorganisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from infections caused by antimicrobial-resistant bacteria.
Not a fit: Patients with infections that are not caused by antimicrobial-resistant microorganisms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel antimicrobial therapies that effectively combat resistant infections.
How similar studies have performed: Previous research has shown promise in identifying bioactive nonribosomal peptides, indicating that this approach could lead to significant advancements in antimicrobial therapy.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MULL, RYAN WYATT — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: MULL, RYAN WYATT
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Anti-Cancer Agents, anti-cancer drug, anti-microbial resistant infection