Finding new antifungal treatments for malaria
Novel Antimalarials from Fungi
This study is looking for new medicines to help fight malaria by testing thousands of natural substances from fungi, especially to find better treatments for children as current drugs are becoming less effective.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Central Florida NIH-funded |
| Lab location | 1 site (Orlando, United States) |
| Project ID | NIH-10815746 on NIH RePORTER |
What this research studies
This research aims to discover new antimalarial compounds by screening a library of fungal secondary metabolites. Researchers will investigate the potential of these compounds to combat malaria, particularly in light of increasing drug resistance to current treatments. The study involves screening 10,000 fungal extracts to identify those with potent antiplasmodial activities and determining their effectiveness against various stages of the malaria parasite. If successful, this research could lead to the development of novel therapies that are more effective in treating malaria, especially in children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years living in malaria-endemic regions, particularly in Southeast Asia.
Not a fit: Patients who are not affected by malaria or those living in non-endemic regions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new and effective treatments for malaria, potentially saving lives, particularly among children.
How similar studies have performed: Other research has shown promise in discovering new antimalarial agents from natural sources, suggesting that this approach could yield significant results.
Where this research is happening
Orlando, United States
- University of Central Florida — Orlando, United States (Active)
Researchers
- Principal investigator: Chakrabarti, Debopam — University of Central Florida
- Study coordinator: Chakrabarti, Debopam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.