Finding natural products to help eliminate HIV reservoirs
Development of natural product inhibitors of Nef for clearance of HIV reservoirs
This study is looking for natural ways to block a protein in HIV that helps the virus hide from the immune system, with the hope that this could improve treatments for people living with HIV and possibly help get rid of the virus in the body.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10772357 on NIH RePORTER |
What this research studies
This research focuses on developing natural product inhibitors that target a specific HIV protein called Nef, which helps the virus evade the immune system. By inhibiting Nef, the goal is to enhance the effectiveness of the immune response against HIV-infected cells. The research employs high-throughput assays to identify these inhibitors and aims to combine them with existing therapies to clear HIV reservoirs in the body. Patients may benefit from new treatment strategies that could lead to better management or potential eradication of HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who have not achieved viral eradication despite antiretroviral therapy.
Not a fit: Patients who are not infected with HIV or those who have already achieved complete viral suppression may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that significantly reduce or eliminate HIV reservoirs in patients.
How similar studies have performed: While the approach of targeting Nef is relatively novel, previous studies have shown promise in using latency reactivation strategies to address HIV reservoirs.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Sherman, David H — University of Michigan at Ann Arbor
- Study coordinator: Sherman, David H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.