Finding microbial genes that affect human diseases
Official title: Computational methods for discovery of disease-modulating microbial genes
Funded at Wistar Institute · NIH-11077254 · Data updated 2026-11-12
This study is looking at how tiny germs in our gut and sick tissues might be linked to diseases like cancer and immune disorders, and it aims to find new ways to spot these germs to help improve treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wistar Institute NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | May 1, 2024 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $371,441 |
| NIH project number | 5R01LM014503-02 |
| Project ID | NIH-11077254 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with cancer or immune diseases who may benefit from enhanced diagnostic and treatment strategies.
✕Less likely to help
Patients with conditions unrelated to microbial influences or those not diagnosed with cancer or immune diseases may not receive benefits from this research.
What this research studies
This research investigates the role of microbial genes found in the gut and diseased tissues in relation to various human diseases, including cancer and immune disorders. By developing advanced computational methods, the project aims to detect and quantify these microbial genes, which are often overlooked in current diagnostic practices. The researchers will utilize RNA sequencing to identify microbial gene expression and create a comprehensive database of these genes across different conditions. This approach could lead to the discovery of new biomarkers and improve treatment strategies for patients.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment options for patients with diseases influenced by microbial genes.
How similar studies have gone: Other research has shown promise in linking microbial genes to human diseases, suggesting that this approach could yield significant insights.
Where this research is happening
-
Wistar Institute
Philadelphia, United States Active
Researchers
- Principal investigator: Auslander, Noam — Wistar Institute
- Study coordinator: Auslander, Noam
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.