Finding medicines to fix HIV-related metabolism problems
An Innovative Approach to Identify Correctors of Metabolic Complications in HIV
['FUNDING_R01'] · SCRIPPS RESEARCH INSTITUTE, THE · NIH-11239127
This project looks for new small molecules that could correct metabolic problems in people living with HIV.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SCRIPPS RESEARCH INSTITUTE, THE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-11239127 on ClinicalTrials.gov |
What this research studies
Researchers will use automated, high-throughput lab tests to screen about 666,000 compounds against a protein linked to metabolic complications in HIV and chronic inflammation. Promising 'hits' will go through follow-up and orthogonal tests to remove false positives and check for off-target effects. The team will prioritize chemical series and refine them toward selective compounds that can be developed further. Work is carried out across labs at Scripps Research in La Jolla and UF Scripps in Jupiter, using robotics and drug-discovery expertise.
Who could benefit from this research
Good fit: People living with HIV who have metabolic complications such as high cholesterol, increased weight, or metabolic syndrome would be the likely future candidates for trials based on these discoveries.
Not a fit: People without HIV or those whose metabolic issues are solely due to non-HIV causes are unlikely to benefit directly from this laboratory-based drug-discovery project.
Why it matters
Potential benefit: If successful, this could lead to new drugs that reduce dyslipidemia, obesity, and cardiovascular risk in people with HIV.
How similar studies have performed: High-throughput screening has produced useful drug leads in other diseases, but turning initial hits into safe, effective medicines typically takes many additional steps and time.
Where this research is happening
LA JOLLA, UNITED STATES
- SCRIPPS RESEARCH INSTITUTE, THE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SANNA, PIETRO P — SCRIPPS RESEARCH INSTITUTE, THE
- Study coordinator: SANNA, PIETRO P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus